• Quad versus Atripla

    Currently, there is only one option available for people who would like to take their entire antiretroviral (ARV) regimen in a single pill: Atripla. Two other all-in-one pills are following closely behind, however. One of those is Gilead’s Quad pill, which contains the company’s integrase inhibitor, elvitegravir, boosted by cobicistat, and paired with tenofovir and emtricitabine. Early news on the Quad pill from a phase II study—reported in early 2010 at the 17th Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco—was favorable.

    At this year’s ICAAC, Richard Elion, MD, from the Whitman Walker Clinic in Washington, DC, presented 48-week data from the same study (Study 236-0104), which compared the Quad pill with Atripla in 71 people living with HIV who were starting ARV treatment for the first time. Forty-eight people were randomized to take the Quad pill, and 23 were randomized to take Atripla.

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